The low-light CMOS image sensor(CIS),is the new design of the latest CMOS image sensor technology at sensor pixel and read-out circuit,which improves the sensitivity,SNR and dynamic range and provides excellent images at low light levels. Compared with the conventional vacuum detectors,CIS is a new type of solid-state device which does not require a vacuum and high voltage environment.The whole process of conversion and amplifying of photoelectric,signal read-out,and digitization can be achieved in the semiconductor materials. With advantages of high sensitivity,small size,light weight,low power consumption ,and expansibilityetc.,CIS device can be applied to military, security, industrial, scientific and many other fields.